Protein Details: Cation channel sperm-associated auxiliary subunit delta
Protein ID
ICDB_Pro_0097
Protein Name
Cation channel sperm-associated auxiliary subunit delta
Gene Name
Catsperd; Tmem146
Organism
Rattus norvegicus (Rat)
Length
803 amino acids
AlphaFoldDB
AF-B5DFM7-F1-model_v4.pdb
Function
Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
Sequence
MLMLMLAAVATVVRAQTVCRFRTVRTGKVFANPVTLEGDLLFYAFSNTVVVKNVCKTDIAVYLGQRVFITKNRFEASILPLTIPKSMEVKMPSITSAHFVSDAMILFVIDGKVYSYNFIEDIWRTVNGITEPVSHISGDPCCFEGYFCLELSNNLFAYFRGGQMPGTNIYFSNNGGFSFELLNSDRMSHLKGLLGGIFHFHSLSQVGILLVENNLGTFHYLEYPLNHSTGVPFLYESPLEVIIKPQQRGFLILWNQKTLLVSSNSGQIVEAMQLMEEGNINDLNVEHAKLTIHSIASNTYELAFLVEQDQLYYGSQSYMGNYIIKLSNQQFWSEEASVHFWDVGMLEVLTPVSDPYFPAFDFKKCLVNVQLALMDQSLQLEPCNVEFLESTMEDRMFIIDMNSKLKLSALMVPRKGMNPTPLVMVSNPHALGFKANLTQFGNMYDGNSKFKLDIELQQQQHWGNSELNFTASIKHEAISSITVDIADKTLSCVDLKPLSTLISVGCDLTKKVIVQNKISACAMGILDPVLLQKNYSYTIEKEAYNPTSYSGEAQDDLIVFYQYKELGCPRLVYYDKPWKPVVELWKDGTLEEIMNAEYVILELNGIVTYSYSLTAATAHCRSQPQNWSIFKEDAEKPSLWNRETYVSCHEDNQDNPLLWPNVEYQILGGRTDNKIIFGQRNGIYTFYLTVVDPYYSYCDLNTIFSVYVYGALPVAEFRPMTSILLMVTVTLFTMWLAYAIPKQLRTERGRRLTGFCFQIFKYCPGICTCAWLRGKMRRGLRSRRVKDQPEKIPQIGKKPDIKK
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1038/nature02426; 10.1101/gr.2596504
RefSeq
NP_001128456.1 [B5DFM7-2]; XP_006244402.1 [B5DFM7-1]